![]() ![]() J Basic Clin Physiol Pharmacol 2021.īezdek S, Hdnah A, Sezin T, Mousavi S, Zillikens D, Ibrahim S, et al. Strain specific response of mice to IMQ-induced psoriasis. JCI Insight 2017 2(11).īadanthadka M, D’Souza L, Salwa F. Tristetraprolin expression by keratinocytes controls local and systemic inflammation. J Immunol 2011 187(2):951–9.Īndrianne M, Assabban A, La C, Mogilenko D, Salle DS, Fleury S, et al. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Clin Invest 2008 118(1):205–16.Īdamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. Scale bar = 100μm for each mouse image scale bar = 50μm for each human image.Ībdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, et al. Psoriasiform mouse skin also contains neutrophilic microabscesses, however imiquimod skin has an abundance of neutrophils in the dermis. Neutrophils are primarily contained to the microabscesses in plaque psoriasis and can be seen exiting the dermal vasculature (*). Psoriasis plaque and psoriasiform mouse skin contain dense immune cell infiltrate comprised of T cells, myeloid cells (not shown), and Munro-like neutrophilic microabscesses (grey arrows). Mouse skin has a muscle layer called the panniculus carnosus (black arrow) not found in human skin. ![]() Mouse skin has fur, more hair follicles, and hair follicle epidermis thickens in animal models of psoriasis (e.g., white stars). Rete pegs occur only in psoriasis patient plaque (black stars), not mouse skin. Acanthosis (epidermal thickening) is a key characteristic present in psoriasis patient and mouse model skin. H&E staining of lesional psoriasis skin and dorsal skin from Klk6 +, KC-Tie2, and imiquimod (IMQ) models.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |